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pentobarbital will reduce the extent or result of pioglitazone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.pentobarbital will lower the level or impact of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the level or impact of nelfinavir by impacting hepa